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However, this relationship has not been observed in animal-derived peptides ( Bacillus mojavensis A21 protease fraction (HFFD + GPH-A) and triggerfish protease fraction (HFFD + GPH-TF), respectively, could reduce blood glucose level and hepatic glycogen and protect the kidney of high-fat-high-fructose diet (HFFD)-fed rats by reversing the HFFD-induced uric acid reduction and creatinine level increase in serum and preventing some HFFD-induced changes in the kidney (including tubular dilatation, glomerular space, vacuolization, and epithelial cells necrosis of the proximal tubule) (Figure 10C)